Prerequisite(s): BIOL 230 with a grade of C- or higher and BIOL 380 with a grade of C- or higher. The course will examine the associations among nucleic acid sequence (RNA and DNA), structure, and function in complex biological systems, while treating these systems as biological databases. Both computer program-based and laboratory methods will be discussed to better understand the relationship between nucleic acid sequence and function. Future opportunities and current limitations of genome analyses will be critically addressed.