This course covers advanced topics in biocompatibility and the body's response to foreign materials, with an emphasis on material properties and the cell and molecular biology of the immune system. The course explores the various signaling mechanisms used by cells when presented with foreign and engineered antigens, and then applies engineering principles to the discovery and design of novel biomaterials and therapeutics that are biocompatible. State of the art topics in current literature related to biocompatibility and immunoengineering will be explored.