This lecture course deals with complex biochemical processes involving the interaction of numerous classes of biomolecules. Specifically the course focuses on the interplay of proteins, lipids, carbohydrates, and nucleic acids in the cellular response and adaptation to the environment, both locally in the cell and of the organism as a whole. The course relies on both traditional descriptions of biochemical processes and the inclusion of primary literature sources to analyze experimental data, explain methodology, and introduce cutting edge concepts.