This course will provide and in-depth overview of several synthetically useful chemical methodologies, reagents, and reactions that are essential in synthesis of organic pharmaceuticals. Some of the general categories of reactions to be discussed in this course include reduction, oxidation, protecting groups, and carbon-carbon bond forming reactions. This course will survey a broad and diverse range of enantioselective, diastereoselective, chemoselective, and/or regioselective chemical transformations critical for the preparation of medicinal compounds. This course would suit the needs of graduate and senior undergraduate students who intend to pursue careers in the field of pharmaceutical sciences.