This course will cover fundamental topics in biochemistry and how they relate to human health and disease. This begins with the introduction of the biomolecules that are central to human metabolism at the cellular and organismal level. We then explore the bioenergetic and thermodynamic principles that govern this metabolism, as well as how the body uses enzymes to harness these properties. We then move onto the study of the biochemical pathways that underlie human metabolism and how these pathways can be dysregulated in human disease.